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The railroad saw the creation of Calhoun, named for statesman John C. Calhoun.  Son-in-law Thomas Green Clemson deeded the Calhoun plantation to South Carolina for an agricultural and mechanical college, and the town was renamed Clemson.

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American Revolution Patriot General Andrew Pickens moved here after the war and became one of the Pendleton District founders. The Pickens District came with the 1826 division, and in 1868 Pickens was divided to created Oconee and Pickens counties. The present city of Pickens became the courthouse seat.
 
Central was midway on the railroad between Atlanta and Charlotte. Liberty is named for Salubrity springs, and Easley is named for William K. Easley. Textile developer D.K. Norris named Norris and Cateechee. Dacusville is named for an early citizen and Six Mile is named for a stream. Pumpkintown was a pioneer crossroad.

 Sites & Attractions

Clemson University: Fort Hill, other sites. Tour Center on Campus

South Carolina Botanical Garden, Clemson University

Pickens County Museum, 307 Johnson Street, Pickens

Hagood-Mauldin House & Irma Morris Fine Art Collection, N. Lewis Street, Picken

Hagood Mill, U.S. 178, north of Pickens

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